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課程名稱 |
環境與食品分離技術
Separation Techniques in Environmental and Food Analysis |
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開課學期 |
108-1 |
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授課對象 |
公共衛生學院 食品安全與健康研究所 |
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授課教師 |
陳鑫昌 |
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課號 |
IFSH7013 |
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課程識別碼 |
851 M1130 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期二6,7(13:20~15:10) |
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上課地點 |
公衛207 |
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備註 |
總人數上限：10人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1081IFSH7013 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
1. 基礎理論及應用: 本課程將介紹氣態、液態和固態樣品等各種樣品基質的傳統和現代分離/萃取技術分離技術，並以SCI文章和應用內容與學生進行討論。同時討論每種技術的優點、侷限性及其關鍵技巧。
2. 實作課程: 實際操作現行法規常用之萃取技術，如SPE、LPME及QuEChERS等，並了解其技巧及問題解決。
1. Fundamental and Application: This course offers consistently traditional and modern techniques of separation/extraction for gas-phase, liquid-phase, and solid-phase samples, incorporating SCI articles and applications. Advantages and limitation of each technique will also be discussed.
2. Practice Course: Modern extraction approaches, e.g. SPE, LPME, and QuEChERS, will be practiced by students to learn how to perform the extraction techniques and troubleshoot problems. |
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課程目標 |
1. Enhance students’ knowledge in separation science, and how to perform separation techniques to purify/isolate compounds.
2. Figure out the differences and practical in various separation/extraction techniques, and how to select an appropriate sample pretreatment approach to extract target analytes in the specific matrix.
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課程要求 |
無
None |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註： Appointment |
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指定閱讀 |
John R. Dean, Extraction Techniques in Analytical Sciences, John Wiley & Sons, Inc., 2010. (e-book is available) |
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參考書目 |
Basics:
1. Elena Ibanez and Alejandro Cifuentes, Green Extraction Techniques: Principles, Advances, and Applications (eBook ISBN: 9780444638694). Elsevier Science Serials, 2017
2. Wenkui Li, Wenying Jian, Yunlin Fu, Sample Preparation in LC-MS Bioanalysis (ISBN: 978-1119274292), John Wiley & Sons, Inc., 2019.
3. Somenath Mitra, Sample Preparation Techniques in Analytical Chemistry, John Wiley & Sons, Inc., 2003. (e-book is available)
Advances
1. Douglas E. Raynie, Modern Extraction Techniques, Anal. Chem. 2010, 82, 4911–4916.
2. SCI review articles, Articles on Instruments Today |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 (Midterm exam) |
50% |
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2. |
小組報告 (Group projects of Special Topics) |
40% |
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3. |
書面報告 (Projects) |
10% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/10 |
Introduction to Separation Science |
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第2週 |
9/17 |
Standard methods in Environmental and Food Analysis |
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第3週 |
9/24 |
ASPPH 會議，課程調整 |
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第4週 |
10/01 |
Traditional Soxhlet Extraction, ASE, PLE, and their applications |
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第5週 |
10/08 |
Ultra-Sonication, SFE, MAE, SPME and their applications on solid samples |
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第6週 |
10/15 |
Principles and Applications of SPE and SPME
on Liquid/Solid samples |
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第7週 |
10/22 |
Novel techniques for Food Samples: QuEChERS
Traditional/Novel Technique for liquid samples (I): LLE and LPME (SDME, HF-LPME and DLLME) |
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第8週 |
10/29 |
Practice of SPE, dSPE,SLE and QuEChERS (10F Lab) |
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第9週 |
11/05 |
Midterm Exam (期中考) |
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第10週 |
11/12 |
SLE, dSPE, MSPD and their applications |
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第11週 |
11/19 |
Sample Preparation for Mass Spectrometry-Based Proteomics
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第12週 |
11/26 |
Sample Preparation for Mass Spectrometry-Based Metabolomics |
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第13週 |
12/03 |
Air samples (I) - Whole air sampling and solid sorbent sampling, Impinger sampling and Filter sampling |
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第14週 |
12/10 |
Filtration for Sample Preparation |
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第15週 |
12/17 |
QA/QC in Sample Preparation |
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第16週 |
12/24 |
Green Extraction Techniques |
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第17週 |
12/31 |
Special topics (I) |
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第18週 |
1/6 |
Special topics (II) |
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